Research
DIABETES EXPERT DEVELOPS ARTIFICAL PANCREAS PDF Print E-mail

16th Sep 2010

A researcher from Leicester has developed an artificial pancreas which could revolutionise the treatment of diabetes and put a stop to daily injections.

Professor Joan Taylor from De Montfort University (DMU) is developing a device which would be implanted into the body between the lowest rib and the hip and would be topped up with insulin every few weeks. 

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Experimental glucose sensing implant hits the news PDF Print E-mail

glucose_sensor_LARGE29/7/2010

Developed by Professor David Gough’s team at the University of California in San Diego, with support from JDRF, the prototype implantable glucose sensor is currently being tested in pigs.

The device is inserted under the skin in a surgical procedure, and gives a reading of how glucose levels in the body are changing moment to moment by comparing two chemical reactions in the body.

The device is currently quite large – shaped like an ice-hockey puck, it is just under 4 cm in diameter and over 1cm thick. It transmits readings wirelessly to a remote sensor that can pick up the signals up to 3.5m away. The team hope to be able to make the sensor smaller as they develop the technology further, and speculate that they may be able to send readings to mobile phones or other devices.

The sensor has been implanted into two pigs so far. The first pig to receive the device has now had the implant for 1 year and the research team say it has been working well through out that time. A second pig is showing similar good results after more than 6 months. However neither pig has diabetes.

The team are planning to move to human trials of the device soon and hope that the implantable system may in the future provide an alternative to the currently available continuous glucose sensors, which must be changed every few days.

The story has been covered by a number of news outlets including the Daily Mail and the news blog from top scientific publisher Nature.

Image: C. Bickel/Science Translational Medicine © 2010 AAAS

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Click and Pump Insulin Delivery Device from Calibra Medical PDF Print E-mail

26th July 2010CalibraSideView-798705

Calibra Medical out of Redwood City, CA has received FDA approval to market its Finesse insulin patch-pen. Earlier this year, Bernard Farrell over at his Diabetes Technology Blog had a chance to get a closer look at the fully mechanical device.

A snippet:

The design itself is slim enough that it should be invisible under most clothing. It contains a reservoir that holds 200 units of insulin.

To dispense insulin you simply squeeze the two small buttons on both sides of the Finesse, the unit clicks with each press so you can count the number of units delivered. There's an interlocking mechanism, so both buttons must be pressed before any insulin is bolused, this is designed to avoid accidental dispensing of insulin. It's a bolus-only device, so users will still need shots of long-acting insulin.

Original Article

Further reading by Bernard Farrell

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Study: Insulin Pump Better Than Injections PDF Print E-mail
Researchers Say 'Artificial Pancreas' for Type 1 Diabetes May Be Reality in Several Years

July 21, 2010 -- Encouraging research raises new hopes that a long awaited "artificial pancreas" to treat patients with type 1 diabetescould be available in the U.S. within the next few years, experts say.

In the largest and longest study ever of an insulin pump with a continuous glucose sensor, patients who used the device achieved better control of their blood sugar than patients taking insulin injections.

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Big partnership – small needles PDF Print E-mail

19/01/2010

JDRF has joined forces and medical technology company BD (Becton, Dickinson and Company) to launch an innovative programme to make insulin pumps more effective and more user-friendly.

Key to this partnership will be working with BD’s ‘microneedle’ technology. Microneedles are tiny needles that could deliver insulin to just beneath the skin, which would not only increase the speed at which insulin is delivered to the body, but may also be virtually pain free.

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Artificial Pancreas: a new leap forward PDF Print E-mail

13/01/2010

JDRF_and_Animas1

Today Juvenile Diabetes Research Foundation International announced an innovative partnership with Animas Corporation to begin work on bringing an automated ‘artificial pancreas’ closer to reality for people living with type 1 diabetes.

Animas, a Johnson & Johnson company, is a leading manufacturer and distributor of insulin delivery and glucose management systems. JDRF is a global leader in research leading to better treatments and cures for type 1 diabetes.

This major industry initiative within the JDRF Artificial Pancreas Project has an ambitious set of objectives. Not only will the partnership aim to develop a ‘first generation’ partially automated system to manage type 1 diabetes and conduct extensive clinical trials for safety and efficacy, but it will also aim to submit the system for regulatory approval in the next four years.

The idea behind the Artificial Pancreas Project is to link two existing technologies, insulin pumps and continuous glucose sensors. This first generation system aims to increase the time people with type 1 spend in the ‘target’ range – avoiding hypoglycaemia (low blood glucose levels) and serious hyperglycaemia (high blood glucose levels).

 

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